Publications

Boroshok, A. L., McDermott, C.L., Fotiadis, P., Park A.T., Tooley, U.A., Gatavins, M.M., Tisdall M.D., Bassett, D.S., & Mackey, A.P. (2023). Individual differences in T1w/T2w ratio development during childhood. Developmental Cognitive Neuroscience.pdf

McDermott, C.L., Lee, J., Park, A.T., Tooley, U.A., Boroshok, A. L., Hilton, K., Linn, K.A., Mupparapu, M., Mackey, A.P. (2023). Developmental correlates of accelerated molar eruption in early childhood. Biological Psychiatry: Global Open Science. pdf

Tooley, U.A., Park, A. T., Leonard, J. A., Boroshok, A. L., McDermott, C.L., Tisdall, M.D., & Mackey, A.P. (2022). The age of reason: Functional brain network development during childhood. The Journal of Neuroscience. 42(44):8237–8251. pdf

Park, A. T., Richardson, H., Tooley, U.A., McDermott, C.L., Boroshok, A. L., Ke, A., Leonard, J. A., Tisdall, M.D., Deater-Deckard, K., Edgar, J.C., & Mackey, A.P. (2022). Early stressful experiences are associated with reduced neural responses to naturalistic emotional and social content in children. Developmental Cognitive Neuroscience. 57:101152. pdf

Richie-Halford, A., Cieslak, M., Ai, L. ... The Fibr Community Science Consortium including Tooley, U.A. ... Satterthwaite, T. D., & Rokem, A. (2022). An analysis-ready and quality controlled resource for pediatric brain white-matter research. Scientific Data. 9, 616. pdf

Boroshok A.L., Park A.T., Fotiadis, P., Velasquez G.H., Tooley, U.A. , Simon K.R., Forde J.C.P., Tisdall M.D., Cooper E.A., & Mackey A.P. (2022). Individual differences in frontoparietal plasticity in humans. npj Science of Learning. 7, 14. pdf

Tooley, U.A. Bassett, D.S. & Mackey, A.P. (2022). Functional brain network community structure in childhood: Unfinished territories and fuzzy boundaries. Neuroimage. 118843. pdf

Mahadevan, A.S., Tooley, U.A. , Bertolero, M.A., Mackey A.P., & Bassett, D.S. (2021). Evaluating the sensitivity of functional connectivity measures to motion artifact in resting-state fMRI data. Neuroimage. 118408. pdf

McDermott, C.L., Hilton, K., Park, A.T., Tooley, U.A. , Boroshok, A.L., Mupparapu, M., Scott, A.M., Bumann, E.E., Mackey, A.P. (2021). Early life stress is associated with earlier emergence of permanent molars. Proceedings of the National Academy of Sciences. 118(24) e2105304118. pdf

Cieslak, M., Cook, P.A., He, X., Yeh, F.H., Dhollander, T., Adebimpe, A., ... Tooley, U.A. , . & Satterthwaite, T.D. (2021). QSIPrep: A robust and unified workflow for preprocessing and reconstructing diffusion MRI. Nature Methods. 18, 775-778. link

Tooley, U.A., Bassett, D.S., & Mackey, A.P. (2021). Environmental influences on the pace of brain development. Nature Reviews Neuroscience, 22, 372–384. pdf

Park, A. T., Tooley, U.A. , Leonard, J. A., Boroshok, A. L., McDermott, C.L., Tisdall, M.D., & Mackey, A.P. (2021). Early childhood stress is associated with blunted development of ventral tegmental area connectivity. Developmental Cognitive Neuroscience, 47:100909. pdf

Tooley, U.A., Mackey, A. P., Ciric, R., Ruparel, K., Moore, T. M., Gur, R. C., Gur, R. E., Satterthwaite, T. D., Bassett, D. S. (2020). Associations between neighborhood SES and functional brain network development. Cerebral Cortex, 30(1), 1-19. pdf

Tooley, U., Makhoul, Z., & Fisher, P.A. (2016). Nutritional status of foster children: implications for cognitive and behavioral development. Children and Youth Services Review, 70, 369-374. pdf

Edgin, J.O., Tooley, U., Demara, B., Nyhuis, C., Anand, P., & Spano, G. (2015). Sleep disturbance and expressive language development in preschool-age children. Child Development, 86(6), 1984-1998. pdf

Submitted or in prep

Tooley, U.A., Latham, A., Kenley, J.K., Alexopoulos, D., Smyser, T., Warner, B.B., Shimony, J.S., Neil, J.J., Luby, J.L., Barch, D.M., Rogers, C.E., & Smyser, C.D. Effects of the early environment on the pace of brain network development: Evidence from the first three years of life. In prep.

Selected publications

The age of reason: Functional brain network development during childhood. The Journal of Neuroscience (2022). Human childhood is characterized by dramatic changes in the mind and brain, yet little is known about the remodeling of cortical connectivity during this developmental period. Here we found that, from age 4 to age 10, age is associated with pronounced development in both visual and medial prefrontal areas of the brain, at two ends of a gradient from perceptual, externally oriented cortex to abstract, internally oriented cortex. Children with more mature patterns of brain connectivity had better cognitive skills. This research challenges the traditional notion that sensory brain areas develop first and association brain areas last, and suggests that as brain connectivity becomes more specialized, children become more able to reason about the world and their place in it. schematic_tooley

Environmental influences on the pace of brain development. Nature Reviews Neuroscience (2021). Childhood socioeconomic status (SES), a measure of the availability of material and social resources, is one of the strongest predictors of lifelong well-being. Here, we suggest that experiences associated with childhood SES affect not only the outcome but also pace of brain development, with implications for neural plasticity. We argue that higher childhood SES is associated with protracted structural brain development and a prolonged trajectory of functional network segregation, ultimately leading to more efficient cortical networks in adulthood. We hypothesize that greater exposure to chronic stress accelerates brain maturation, whereas greater access to novel positive experiences decelerates maturation. We also discuss the impact of variation in the pace of brain development on plasticity and learning.

Press
What Children Lose When Their Brains Develop Too Fast. Wall Street Journal, Dec 9, 2021, Alison Gopnik

schematic_tooley Associations between neighborhood SES and functional brain network development. Cerebral Cortex (2020). It is intuitively obvious to anyone who has watched a child turn into a teenager that our brains undergo vast changes as we grow up. But how might these changes differ for a child living in Brooklyn as compared to a child living in Detroit? Our recent work finds that intrinsic brain networks become more segregated, or clustered into subgroups, as children get older, and that the socioeconomic status (SES) of the neighborhood they live in affects this process. We found that youth living in high-SES neighborhoods show stronger age-related changes in brain network segregation than youth living in low-SES neighborhoods.

While children in high-SES neighborhoods start out with lower levels of brain network segregation, by age 22, they show higher levels of segregation than youth in low-SES neighborhoods, a pattern that is suggestive of faster brain development in the youth in high-SES neighborhoods. These effects were strongest in areas of the brain important for judgment, motivation, and both sensory and motor processing. Our findings shed light on the relationships between intrinsic brain networks and age, and on how the local environment might shape these relationships, underscoring the importance of the neighborhood during development.


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